http://ccwf.cc.utexas.edu/~nhart/Status_calculator.htm
I just found this today... the results are pretty shocking as some mixes that I would have never even thought of become absolute beasts in the long run. Maybe if you want to know what you are heading up to check this out. If you are planning o trying out weird subs this can help a lot.
-EDIT-
(an example of a mix that can become a pure beast is a PLD/DRK or DRK/PLD... either way they are very well off all around)