Its been 20 years since Owen last saw C-3PO. There's also the color switch and most protocol droids looked nearly if not exactly the same so even if Owen remembered C-3PO he probably wouldn't have recognized him.
Also...
Midi-chlorians do not speed up the aging process. Midi-chlorians are the physical side of the Force. You must have gotten them mixed up with the clones, whose aging process were speeded up so that they could have a fully mature clone in less that 18 years.
And Shmi is not the mother of Owen. Lars had Owen in a previous marriage, or at least a previous relationship.
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