It's sad when you have to disect a comic.
James, Spoon, and Cloud are discussing their experiences of Metriod Prime while at E3. James pretended to be retarded so that they would let him view it at a closer distance. Spoon has wet himself in the past from being overally excited. He says the saying "I smell a ____". Where almost anything can be inserted the most common being "I smell an Oscar". To clear confusion about him peeing his pants and that saying he makes up that little thingy about the distinction between the two smells. Cloud is James's cousin who is, well, Cloud. While James and Spoon are talking about their experiences Cloud just says something stupid like with his janitor. Which is true btw. *sigh*