Thanks for the comments.
After drawing the pic in pencil I ink it with micron pens...like really thin markers. The thinest line in the pic is about what the pen is like but the thick lines are also made with it. Started making my lines like that since it's easiest to fix small mistakes. A lot of the thick lines start off much thiner but the correcting and recorrecting ends up making them pretty thick. And lines that change in thickness just look nice.
The pencil is erased after inking and the pic is scanned in pretty large. Edit it a bit to make the black real black and the white real white. Put the drawing on a new layer and set it to multiply so the colors underneath will show. I use the pen tool (which isn't real popular for coloring and my way of coloring is usually done in Illustrator instead of Photoshop) and outline the areas under the areas I want that certain color. (Right-click that layer in the layer window and hit Rasterize to finalize it and get rid of that outline.) I usually do my celshading in this way too but it's awfully hard to get the shapes to look round and neat (which is why I scan my pics in super huge). Ended up not doing any shading in this pic. The smoke was a shape that I added a gradient to to make it appear to fade out. The glasses lens were set on multiply or some other blending thingy. Hopefully I'll be getting a wacom pad soon so I can do a decent coloring job without the tidiness.
http://www.deviantart.com/view/15639599/ Fat-ass was originally a pencil drawing. No inking before scanning. Everythere was done with the pen tool. Each line had to be outlined. It took friggin' months of on and off work. If I had a tablet could have banged it out in half an hour methinks.